Saturday, August 22, 2009

Epigenetic modulation at birth – altered DNA-methylation in white blood cells after Caesarean section

Wiley InterScience :: Journal :: Article PDF

The report states:

"The stress of being born exceeds that of any other critical
life-event. It is fundamental for intact survival during the
transition from foetal to neonatal life. The massive sympathoadrenal
activation during labour (1) mobilizes fuel for the
hypoxic journey through the birth canal and triggers lungliquid
resorbtion (2), thereby facilitating air-breathing
immediately after birth. Labour also activates inflammatory
defence systems (3) and the central nervous system in such
way that the foetus is optimally prepared and adapted for
life outside the womb.
Timing and magnitude of birth stress are altered if delivery
is performed with CS. Infants delivered by elective CS
before onset of labour lack the catecholamine surge seen
after normal VD (1). As compared with normal birth, stress
in infants delivered by CS is also immediate rather than
gradually evolved as during labour. CS may therefore be
maladaptive for the newborn infant and has been associated
with increased short-term neonatal morbidity (4)."

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